Kinetic study of chitosan-alginate biopolymeric nanoparticles for the controlled release of curcumin diethyl disuccinate
The aim of this study was to investigate the release profile, and evaluate the best fitted kinetic model and mechanism, of curcumin diethyl disuccinate (CDD) from chitosan-alginate biopolymeric nanoparticles (CANPs) in simulated gastrointestinal fluids (without enzymes) and simulated body fluid. The CDD-loaded CANPs (CDD-CANPs) were prepared by oil-in-water emulsification and ionotropic gelation under the previously reported optimal condition (3 mg/mL of CDD, 4.05% (w/v) of TweenTM 80 and a chitosan:alginate mass ratio of 0.05:1), which resulted in CDD-CANPs with a favorable particle size (327Â±14 nm), zeta potential (-27.3Â±0.2 mV), encapsulation efficiency (51.2Â±2.2%) and loading capacity (11.2Â±0.8%). The in vitro release of CDD from the CDD-CANPs in simulated gastrointestinal fluid at pH 1.2, 4.5 and 6.8, and simulated body fluid at pH 7.4, indicated that the release of CDD could be controlled, was sustained over at least 72 h and best fit the Korsmeyer-Peppas kinetic model with a Fickian diffusion mechanism. Therefore, CANPs have the potential to be used for the controlled release of CDD in the gastrointestinal tract and blood circulation.Â
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