Cetirizine dihydrochloride tablets comprising two different lubricants with highly loaded colloidal silicon dioxide
AbstractRecently, the fast disintegrating tablet (FDT) has started gaining popularity and acceptance as new drug delivery system. Cetirizine dihydrochloride (CD) is the selective histamine (H-1)-receptor antagonist that is demonstrated to treat the symptoms associated with seasonal and perennial allergic rhinitis which this drug nowadays was prepared in form of FDT. Lubricant typically influences on tablet disintegration time (DT) and wetting time (WT). Therefore, it is important for optimizing the lubricant amount in this dosage form. The purpose of this study was to evaluate the effect of the lubricants (magnesium stearate (Mg-st) and sodium stearyl fumarate (SSF)) on the CD tablet containing highly loaded colloidal silicon dioxide. Mg-St was well known as a high hydrophobic lubricant and that sodium stearyl fumarate (SSF) is less hydrophobic than Mg-St. Therefore, the DT and WT of tablets containing Mg-St increased as the amount of Mg-st increased. However, the DT and WT of FDT were influenced not only by lubricant properties, but by hardness. The polarity of the surface tablets was remarkably decreased by increased the amount of Mg-st which related to the WT of FDT. Therefore, the contact angle of tablets increased and SFE decreased. On the other hand, the polarity of the surface tablets was remarkably increased by increased the amount of SSF.
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