Sodium alginate/aloe vera/mangosteen peel extraction hydrogel composite films with anti-staphylococcal properties as a promising alternative material in biomedical applications
DOI:
https://doi.org/10.55713/jmmm.v36i2.2557Keywords:
hydrogel, Sodium alginate, Mangosteen peel extract, Antibacterial, Biomedical applicationsAbstract
This study focuses on the development of alternative biodegradable hydrogel films from sodium alginate as a matrix and curing into a hydrogel by CaCl2. Thus, the aloe vera (AV) and the crude extract of mangosteen peels (MPE) were additionally blended. The polymer films were prepared using the casting film process, and their morphology, functional groups, water absorption, antibacterial, thermal, and mechanical properties were characterized using SEM, FTIR, water swelling test, disk diffusion method, DSC-TGA, and UTM. The results demonstrated the heterogeneity between the composites and the polymer matrix, and a lower polarity from the decreased %water swelling from 45% to 22%. The mechanical properties showed that the rigidity and strength of the composites were improved, while those without particle blends showed a superior elongation at break. The DSC-TGA revealed a lower melting temperature, but a higher thermal degradation temperature when the additives were added to the films. The Staphylococcus aureus protection provided a clear inhibition zone of 15 ± 1 mm. Lastly, the results of polymer composites hydrogel demonstrated a potential for biomedical applications, particularly as wound dressing materials.
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