Kinetic study of chitosan-alginate biopolymeric nanoparticles for the controlled release of curcumin diethyl disuccinate

Authors

  • Feuangthit Niyamissara Sorasitthiyanukarn Metallurgy and Materials Science Research Institute, Chulalongkorn University
  • Pornchai Rojsitthisak Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University
  • Pranee Rojsitthisak Metallurgy and Materials Science Research Institute, Chulalongkorn University

Keywords:

Controlled release, Kinetic, Nanoparticles; Alginate, Chitosan, Curcumin diethyl disuccinate

Abstract

The aim of this study was to investigate the release profile, and evaluate the best fitted kinetic model and mechanism, of curcumin diethyl disuccinate (CDD) from chitosan-alginate biopolymeric nanoparticles (CANPs) in simulated gastrointestinal fluids (without enzymes) and simulated body fluid. The CDD-loaded CANPs (CDD-CANPs) were prepared by oil-in-water emulsification and ionotropic gelation under the previously reported optimal condition (3 mg/mL of CDD, 4.05% (w/v) of TweenTM 80 and a chitosan:alginate mass ratio of 0.05:1), which resulted in CDD-CANPs with a favorable particle size (327±14 nm), zeta potential (-27.3±0.2 mV), encapsulation efficiency (51.2±2.2%) and loading capacity (11.2±0.8%). The in vitro release of CDD from the CDD-CANPs in simulated gastrointestinal fluid at pH 1.2, 4.5 and 6.8, and simulated body fluid at pH 7.4, indicated that the release of CDD could be controlled, was sustained over at least 72 h and best fit the Korsmeyer-Peppas kinetic model with a Fickian diffusion mechanism. Therefore, CANPs have the potential to be used for the controlled release of CDD in the gastrointestinal tract and blood circulation. 

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References

Wichitnithad, W., Nimmannit, U., Wacharasindhu, S., and Rojsitthisak, P. (2011). Synthesis characterization and biological evaluation of succinate prodrugs of curcuminoids for colon cancer treatment. Molecules. 16(2): 1888-1900.

Ratnatilaka Na Bhuket, P., Niwattisaiwong, N., Limpikirati, P., Khemawoot, P., Towiwat, P., Ongpipattanakul, B., and Rojsitthisak, P. (2016). Simultaneous determination of curcumin diethyl disuccinate and itsactive metabolite curcumin in rat plasma by LC-MS/ MS: Application of esterase inhibitors in the stabilization of an ester-containing prodrug. J. Chromatogr B. 1033-1034: 301-310.

Li, P., Dai, Y., Zhang, J., Wang, A., and Wei, Q. (2008). Chitosan-alginate nanoparticles as a novel drug delivery system for nifedipine. Int J. Biomed Sci. 4(3): 221-228.

Bhunchu, S., and Rojsitthisak, P. (2014). Biopolymeric alginate-chitosan nanoparticles as drug delivery carriers for cancer therapy. Pharmazie. 69(8): 563-570.

Katuwavial, N.P., Perera, A.D.L.C., Samarakoon, S.R.,Soysa, P.,Karunaratne, V., Amaratunga, G.A.J., and Karunaratne, D.N. (2016). Chitosan-Alginate Nanoparticle System Efficiently Delivers Doxorubicin to MCF-7 Cells. J. Nanomater. 2016: Article ID 3178904, 12 pages.

Szekalska, M., Puciłowska, A., Szymańska, E., Ciosek, P., and Winnicka, K., (2016). Alginate: Current use and future perspectives in pharmaceutical and biomedical applications. J. Polym. Sci. 2016: Article ID 7697031, 17 pages.

Lertsutthiwong, P., Rojsitthisak, P., and Nimmannit, U. (2009). Preparation ofturmeric oil-loaded chitosan-alginate biopolymeric nanocapsules. Mater Sci Eng C. 29(3): 856-860.

Motwani, S.K., Chopra, S., Talegaonkar, S., Kohli, K., Ahmad, F.J., and Khar, RK. (2008). Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: Formulation, optimization and in vitro characterisation. Eur.J Pharm Biopharm. 68(3): 513-525.

Zohri, M., Alavidjeh, M.S., Mirdamadi, S.S., Behmadi, H., Nasrsima, S.M.H., Gonbaki, S. E., Ardestani, M. S., and Arabzadeh, A.J. (2013). Nisin-loaded chitosan/alginate nanoparticles: A hopeful hybrid biopreservative. J. Food Safety. 33(1): 40-49.

Balaji, RA., Raghunathan, S., and Revathy, R.. (2015). Levofloxacin: formulation and in vitro evaluation of alginate and chitosan nanospheres. Egypt Pharm J. 14(1): 30-35.

Loquercio, A., Castell-Perez, E., Gomes, C., and Moreira, RG. (2015). Preparation of chitosan-alginate nanoparticles for trans-cinnamaldehyde entrapment. J Food Sci. 80(10).

Bhunchu, S., Rojsitthisak, P., and Rojsitthisak, P. (2015). Response surface methodology to optimize the preparation of chitosan/ alginate nanoparticles containing curcumin diethyl disuccinate. Adv Mater Res. 1119: 398-402.

Lee, KY., and Mooney, DJ. (2013). Alginate: properties and biomedical applications. Prog Polym Sci. 37(1): 106-126.

Debrassi, A., Bürger, C., Rodrigues, CA., Nedelko, N., Ślawska Waniewska, A., Dłuewski, P., Sobczak, K., and Greneche, J.M. (2011). Synthesis, characterization and in vitro drug release of magnetic N-benzyl-O-carboxymethyl chitosan nanoparticles loaded with indomethacin. Acta Biomater. 7(8):3078-3085.

Chereddy, K.K., Coco, R., Memvanga, P.B., Ucakar, B., DesRieux, A., Vandermeulen, G., and Préat, V. (2013). Combined effect of PLGA and curcumin on wound healing activity. J Control Release. 171(2): 208-215.

Yuksel, N., Kanik, AE., and Baykara, T. (2000). Comparison of in vitro dissolution profiles by ANOVA-based, model dependent and independent methods. Int. J Pharm. 209(1-2): 57-67.

Zhang, Y., Huo, M., Zhou, J., Zou , A., Li, W., Yao, C., and Xie, S. (2010). DD Solver: An add-in program for modeling and comparison of drug dissolution profiles. AAPS J. 12(3): 263-271.

Wang, B., Yu, X-C., Xu, S-F., and Xu, M. (2015). Paclitaxel and etoposide coloaded polymeric nanoparticles for the effective combination therapy against human osteosarcoma.J.Nanobiotechnol.13:22.

Lim, J., Yeap, S., Che, H., and Low, S. (2013). Characterization of magnetic nanoparticle by dynamic light scattering. Nanoscale Res Lett. 8(1): 381.

Segets, D. (2016). Analysis of particle size distributions of quantum dots: From theory to application. KONA Powder Part J. 2016(33): 48-62.

Wu, L., Zhang, J., and Watanabe, W. (2011). Physical and chemical stability of drug nanoparticles. Adv Drug Deliv Rev. 63(6): 456-469.

Yeniay, Ö. (2014). Comparative study of algorithms for response surface optimization. Math Comput Appl. 19(1): 93-104.

Trivedi, D., Karri, VVSR., Spandana, AKM., and Kuppusam, G. (2015). Design of Experiments: Optimization and applications in pharmaceutical nanotechnology. Chem Sci Rev Lett. 4(13): 109-120.

Wang, F., Yang, S., Yuan, J., Gao, Q., and Huang, C. (2016). Effective method of chitosan-coated alginate nanoparticles for target drug delivery applications. J Biomater Appl. 31(1): 3-12.

Gonçalves, C., Pereira, P., and Gama, M. (2010). Self-assembled hydrogel nanoparticles for drug delivery Applications. Materials. 3(2): 1420- 1460.

Yarce, C., Echeverri, J., Palacio, M., Rivera, C., and Salamanca, C. (2016). Relationship between surface properties and In Vitro drug release from a compressed matrix containing an amphiphilic polymer material. Pharmaceuticals. 9(3): 34.

Costa, P., Sousa Lobo, J.M. (2001). Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 13(2): 123-133.

Ramteke, KH., Dighe, PA., kharat, AR., Patil, SV. (2014). Mathematical models of drug dissolution: A review. Sch Acad J Pharm. 3(5): 388-396.

Dash, S., Murthy, P. N., Nath, L., and Chowdhury, P., (2010). Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 67(3): 217-223.

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Published

2018-06-25

How to Cite

[1]
F. N. Sorasitthiyanukarn, P. Rojsitthisak, and P. . Rojsitthisak, “Kinetic study of chitosan-alginate biopolymeric nanoparticles for the controlled release of curcumin diethyl disuccinate”, J Met Mater Miner, vol. 27, no. 2, Jun. 2018.

Issue

Vol. 27 No. 2 (2017)

Section

Original Research Articles

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