Enhancement of cell viability of the (Ba,Ca)(Zr,Ti)O\(_{3}\) and hydroxyapatite composites for bone-repair applications

Jirapa TANGSRITRAKUL; Manita  BOONCHOO; Piyanan BOONPHAYAK; Paweena UPPANAN; Pakkanun KAEWKONG

doi:10.55713/jmmm.v35i1.2153

Authors

Jirapa TANGSRITRAKUL Faculty of Science and Technology, Thammasat University, Pathum Thani 12120, Thailand
Manita BOONCHOO Faculty of Science and Technology, Thammasat University, Pathum Thani 12120, Thailand
Piyanan BOONPHAYAK Department of Industrial Engineering, Engineering Faculty, Naresuan University; Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand
Paweena UPPANAN National Metal and Materials Technology Center, Thailand Science Park, Pathum Thani 12120, Thailand
Pakkanun KAEWKONG National Metal and Materials Technology Center, Thailand Science Park, Pathum Thani 12120, Thailand

DOI:

https://doi.org/10.55713/jmmm.v35i1.2153

Keywords:

Bone Tissue Engineering, Bone-repair applications, Lead-free piezoceramics, Barium Titanate, Hydroxyapatite

Abstract

In this work, the influence of hydroxyapatite (HA) addition to the calcium/zirconium-doped barium titanate (BCZT) piezoceramic was investigated to evaluate its potential for bone-repair applications. The relationship between the physical, electrical, and biological properties of the (100-x)BCZT-(x)HA composite was observed via various techniques. The HA powder was synthesized via precipitation method, whereas the BCZT powder was produced by solid-state reaction to prepare the (100-x)BCZT-(x)HA composites, where x = 0 wt% to 50 wt%. The results showed that the dielectric, ferroelectric, and piezoelectric properties of the (100-x)BCZT-(x)HA composites decreased dramatically as introducing HA into BCZT due to the occurrence of secondary phases from the reactivity between BCZT and HA during sintering. However, although the addition of 10wt%HA into BCZT caused a significant drop of its electrical properties, the enhancement of MC3T3-E1 cell viability was found. Moreover, this work demonstrates for the first time that the number of viable cells observed in the poled 90BCZT-10HA ceramics was significantly higher than that observed in the unpoled BCZT ceramics. These results suggest that the BCZT-HA composite has potential for use in bone-repair applications.

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