Utilization of rice husk ash silica in controlled releasing application


  • Piyawan Prawingwong Department of Chemistry, Thammasat University
  • Chaiyan Chaiya hemical Engineering Division, Rajamangala University of Technology Krungtep
  • Prasert Reubroycharoen Department of Chemical Technology, Chulalongkorn University
  • Chanatip Samart Department of Chemistry, Thammasat University


Mesoporous silica was produced by sol-gel technique using rice husk ash as a silica source which was applied in the drug delivery system. The drug releasing behavior was studied in phosphate buffer using indigo carmine as a drug model. The textural properties of mesoporous silica were characterized and considered with the result of the releasing study. The pore volume and silanol group on the surface of mesoporous silica affected the releasing behavior. The larger pore volume could contain the larger amount of drug which showed fast release. The effect of the silanol group presented an interaction between the drug molecule and silanol group resulting in slower releasing.


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Chareonpanich, M., Namto T., Kongkachuichay P. and Limtrakul, J. 2004. Synthesis of ZSM-5 zeolite from lignite fly ash and rice husk ash. Fuel Process. Technol. 85(15): 1623– 1634.

Chareonpanich, M., Nanta-ngern, A. and Limtrakul, J. 2007. Short-period synthesis of ordered mesoporous silica SBA-15 using ultrasonic technique. Mater. Lett. 61(29): 5153–5156.

Chen, J. F., Ding, H. M., Wang, J. X. and Shao, L. 2004. Preparation and characterization of porous hollow silica nanoparticles for drug delivery application. Biomaterials 25(4): 723-727.

Fagundes, L. B., Sousa, T. G. F., Sousa, A., Silva, V. V. and Sousa, E. M. B. 2006. SBA-15-collagen hybrid material for drug delivery applications. J. Non-Cryst. Solids 352(32): 3496–3501.

Li, Z. Z., Wen, L. X., Shao, L. and Chen, J. F. 2004. Fabrication of porous hollow silica nanoparticles and their applications in drug release control. J. Controlled Release 98(2): 245-254.

Marini, M., Pourabbas, B., Pilati, F. and Fabbri, P. 2008. Functionally modified core-shell silica nanoparticles by One-pot synthesis, Colloids Surf., A. 317(3): 473-481.

Nandiyanto , A.B. D., Kim, S.G., Iskandar, F. and Okuyama, K. 2009. Synthesis of spherical mesoporous silica nanoparticles with nanometer-size controllable pores and outer diameters. Microporous Mesoporous Mater. 120(3): 447-453.

Qu, F., Zhu, G., Huang, S., Li, S., Sun, J., Zhang, D. and Qiu, S. 2006. Controlled release of captopril by regulating the pore size and morphology of ordered mesoporous silica. Microporous and Mesoporous Mater. 92(1-3): 1-9.

Ren, T. Z., Yuan, Z. Y. and Su B. L. 2007. Encapsulation of direct blue dye into mesoporous silica-based materials. Colloids Surf., A. 300(1-2): 79–87.

Witoon, T., Chareonpanich, M. and Limtrakul, J. 2008. Synthesis of bimodal porous silica from rice husk ash via sol–gel process using chitosan as template. Mater. Lett. 62(10-11): 1476–1479.

Zhao,D., Feng, J., Huo, Q., Melosh, N., Fredrickson, G. H., Chmelka, B. F. and Stucky, G. D. 1998. Triblock copolymer syntheses of mesoporous Silica with Periodic 50 to 300 Angstrom Pores. Science 279(5350): 548-552.




How to Cite

P. Prawingwong, C. . Chaiya, P. . Reubroycharoen, and C. Samart, “Utilization of rice husk ash silica in controlled releasing application”, J Met Mater Miner, vol. 19, no. 2, Apr. 2017.



Original Research Articles