Surface properties and in-vitro bioactivity studies of TiO2 nanowire doped transition metal (M=Fe, Co, and Mn)

Misriyani MISRIYANI; Enayah ENAYAH; Z. Ryan  TIAN; Andi Meutiah  ILHAMJAYA

doi:10.55713/jmmm.v36i1.2527

Authors

Misriyani MISRIYANI Department of Medical Education, Faculty of Medicine, University of Alkhairaat, Jl. Diponegoro Palu 94221, Central Sulawesi, Indonesia https://orcid.org/0000-0003-1639-6049
Enayah ENAYAH Department of Cemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, USA
Z. Ryan TIAN Department of Cemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, USA
Andi Meutiah ILHAMJAYA Department of Microbiology, Faculty of Medicine, University of Alkhairaat, Jl. Diponegoro Palu 94221, Central Sulawesi, Indonesia

DOI:

https://doi.org/10.55713/jmmm.v36i1.2527

Keywords:

TiO2 nanowire, Fe, Co, Mn, In-vitro

Abstract

This study investigates the influence of transition metal (Fe, Co, Mn) doping on the surface properties and in-vitro bioactivity of TiO₂ nanowires. It aims to elucidate how transition-metal doping alters the surface behavior and biological response of TiO₂ nanowires, enabling their potential use in biocompatible and magnetically responsive materials. Magnetic TiO₂ nanowires doped with transition metals (M^x+/TiO₂) were successfully prepared by a hydrothermal method using titanium dioxide in alkaline solution. Cations were added with Ti/M^x+molar ratios of 5 to produce Fe/TNW, Co/TNW, and Mn/TNW. Characterization using SEM and XRD determine their surface properties. In-vitro bioactivity tests were conducted by observing the response of C₂C₁₂cells. A cytotoxicity assay determined the effect of TiO₂ Nanowires (5 mg∙mL^‒1) on C₂C₁₂ cell viability at 48 h and 72 h. The results showed that metal-doped TiO₂ nanowires did not significantly affect cell activity, and C₂C₁₂cell differentiation remained. In conclusion, transition metal-doped TiO₂ nanowires do not affect C₂C₁₂ cell activity at certain doses. The magnetic properties of doped TiO₂ nanowires open new opportunities for controlled drug delivery using external magnets.

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