Polymeric eutectic drug delivery system
คำสำคัญ:
Eutectic mixture, menthol, camphor and polymerบทคัดย่อ
Eutectic system is the mixture of at least two substances that suppresses melting point for each of them. The viscosity enhancement of liquid eutectic by polymer addition might increase the viscous environment for retardation of drug release. Typically, there are rare polymers that can dissolve in the liquid eutectic. The aim of this study was to develop the polymeric eutectic delivery system for controlling the drug delivery. Liquid eutectic used as vehicle was prepared by mixing menthol and camphor in various ratios. The obtained lowest viscosity liquid eutectic was used as vehicle in this study. Various polymers were attempted to dissolve in this vehicle to prepare the polymeric eutectic system. Different physical properties of selected polymeric eutectic system were evaluated. Viscosity and rheology were evaluated by brookfield viscometer. Contact angle on glass slide and polydimethylsiloxane (PDMS) coated slide and interfacial tension were measured by goniometer. The polymeric eutectic system selected for controlling the drug delivery contained 30%w/w eudragit® EPO in 1:1 menthol:camphor. This system could be injectable with the newtonian flow property. Contact angle and interfacial tension indicated the hydrophobic characteristic of developed system which it was suitable to sustain the drug release. Various drugs were tested for incorporating in this developed liquid eutectic. Ibuprofen was the most suitable drug because of its high solubility in this system. Solubility of ibuprofen in liquid eutectic was higher than that in water about 1.1×104 folds. Viscosity of liquid eutectic increased as a function of ibuprofen concentration with the newtonian flow behavior. Drug released from this polymeric eutectic system were tested by dialysis tube method at 50 rpm and 37°C. The sustainable drug release could be obtained longer than 7 days with release kinetics primarily as diffusion control. Therefore this developed polymeric liquid eutectic was suitable as the new controlled drug delivery system such as for periodontitis treatment and other injectable dosage forms.Downloads
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Woolfson, A.D., Malcolm, R.K., Campbell, K., Jones, D.S. and Russell, J.A. (2000). Rheological, mechanical and membrane penetration properties of novel dual drug systems for percutaneous delivery. J. Control. Rel. 67(2-3) : 395-408.
Bi, M., Hwang, S.J. and Morris, K.R. (2003). Mechanism of eutectic formation upon compaction and its effects on tablet properties. Thermochim. Acta. 404(1-2) : 213-226.
Stott, P.W., Williams, A.C. and Barry, B.W. (1998). Transdermal delivery from eutectic systems: enhanced permeation of a model drug, ibuprofen. J. Control. Rel. 50(1-3) : 297– 308.
Stott, P.W., Williams, A.C. and Barry, B.W. (2001). Mechanistic study into the enhanced transdermal permeation of a model β-blocker, propranolol, by fatty acids: a melting point depression effect Int. J. Pharm. 219(1-2) : 161-176.
Yong, C.S., Oh, Y.K., Jung, S.H., Rhee, J., Kim, H., Kim, C. and Choi, H. (2004). Preparation of ibuprofen-loaded liquid suppository using eutectic mixture system with menthol. Eur. J. Pharm. Sci. 23(4-5) : 347-353.
Lazerges, M., Rietveld, I.B., Corvis, Y., Céolin, R. and Espeau, P. (2010). Thermodynamic studies of mixtures for topical anesthesia: Lidocaine–salol binary phase diagram. Thermochim. Acta. 497(1-2) : 124-128.
Wahlgren, C.F. & Quiding, H. (2000). Depth of cutaneous analgesia after application of a eutectic mixture of the local anesthetics lidocaine and prilocaine (EMLA cream). J. Am. Acad. Dermatol. 42(4) : 584-588.
Nazzal, S., Smalyukh, I.I., Lavrentovich, O.D. and Khan, M.A. (2002). Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. Int. J. Pharm. 235(1-2) : 247-265.
Morrison, H.G., Sun, C.C. and Neervannan, S. (2009). Characterization of thermal behavior of deep eutectic solvents and their potential as drug solubilization vehicles. Int. J. Pharm. 378(1-2) : 136-139.
Lindberg, D., Revenga, M. and Widersten, M. (2010). Deep eutectic solvents (DESs) are viable cosolvents for enzyme-catalyzed epoxide hydrolysis. J. Biotechol. 147 (2010) : 169-171.
Miller, R.F. (2009). Deep eutectic solvents and applications. US patent 20090247432.
Domınguez de Marıa, P. and Maugeri, Z. (2011). Ionic liquids in biotransformations: from proof-of-concept to emerging deep-eutecticsolvents. Curr. Opin. Chem. Biol. 15(2) : 220-225.
Patel, T., Ishiuji, Y. and Yosipovitch, G. (2007). Menthol: A refreshing look at this ancient compound. J. Am. Acad. Dermatol. 57(5) : 873-878.
Al-Bayati, F.A. (2009). Isolation and identification of antimicrobial compound from Mentha longifolia L. leaves grown wild in Iraq. Ann. Clin. Microbiol. Antimicrob. 8:20 doi : 10.1186/1476-0711-8-20.
Chang, C.P., Leung, T.K., Lin, S.M. and Hsu, C.C. (2006). Release properties on gelatin-gum arabic microcapsules containing camphor oil with added polystyrene. Colloids. Surf. B. 50(2) : 136–140.
Shunying, Z., Yang, Y., Huaidong, Y., Yue, Y. and Guolin, Z. (2005) Chemical composition and antimicrobial activity of the essential oils ofChrysanthemum indicum. J. Ethnopharmacol. 96(1-2) : 151–158.
Kotan, R., Kordali, S., Cakir, A., Kesdek, M., Kaya, Y. and Kilic, H. (2008). Antimicrobial and insecticidal activities of essential oil isolated from Turkish Salvia hydrangea DC. ex Benth. Biochem. Syst. Ecol. 36(5-6) : 360-368.
Phaechamud, T. and Tuntarawongsa, S. (2012). Menthol, borneol, camphor and WS-3 eutectic mixture. Adv. Mat. Res. 506 : 355-358.
Evonik Rӧhm GmbH Pharma Polymers. EUDRAGIT® Acrylic Polymers for Solid Oral Dosage Forms : 1-14.
Flora, J.R.V., Baker, B., Wybenga, D., Zhu, H. and Aelion, C.M. (2008). Preparation of acidic and alkaline macrocapsules for pH control. Chemosphere. 70(6) : 1077–1084.
Elgindy, N. and Samy, W. (2009). Evaluation of the mechanical properties and drug release of cross-linked Eudragit films containing metronidazole. Int. J. Pharm. 376(1-2) : 1-6.
Scherlund, M., Welin-Berger, K., Brodin, A. and Maimsten, M. (2001). Local anaesthetic block copolymer system undergoing phase transition on dilution with water. Eur. J. Pharm. Sci. 14(1) : 53-61.
Kelly, H.M., Deasy, P.B., Ziaka, E. and Claffey, N. (2004). Formulation and preliminary in vivo dog studies of a novel drug delivery system for the treatment of periodontitis. Int. J. Pharm. 274(1-2) : 167-183.
Chotichanapibal, B. (1998). Clinical effects of the intra-pocket irrigation with tetracycline hydrochloride solution as an adjunct to root planning in adult periodontitis [dissertation]. Bangkok: Chulalongkorn University.
Norling, T., Loding, P. and Engstrom, S. (1992). Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease. J. Clin. Peridontol. 19(9) : 687-692.
Van Steenberghe, D. (1994). Antibiotic gels for periodontal disease. Drug and Therapeutic Bulletin. 32(6) : 43-44.
Friskopp, J., Nilsson, M. and Isacsson, G. (2001). The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix®) for periodontal scaling/root planing. J. Clin. Periodontol. 28(5) : 453-458.
Hargreaves, K. and Abbott, P.V. (2005). Drugs for pain management in dentistry. Aust. Dent. J. Suppl. 50(4) : S14-S22.
Parirokh, M., Ashouri, R., Rekabi, A.R., Nakhaee, N., Pardakhti, A. and Askarifard, S. (2010). The effect of premedication with ibuprofen and indomethacin on the success of interior alveolar nerve block for teeth with irreversible pulpitis. J. Endod. 36(9) :1450-1454.
Williams, R.C. (2008). Host modulation for the treatment of periodontal diseases. Compend. Contin. Educ. Dent. 29(3) : 160-168.
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